Biosynthesis of 9α,15-Dihydroxy-11-ketoprost-13-enoic Acid
نویسندگان
چکیده
منابع مشابه
On the Metabolism of Prostaglandins E, and E, in the Guinea Pig*
5/3,7a-Dihydroxy-11-ketotetranor-prostanoic acid was the major metabolite excreted in the urine of guinea pigs injected with tritium-labeled prostaglandin E1, prostaglandin EP, 110~ ,15~-dihydroxy-9-ketoprost-5-enoic acid, lla-hydroxy-9,15-diketoprostanoic acid, and 11~hydroxy-9,15diketoprost-5-enoic acid. A method was developed for quantitative determination of 5p ,‘7cr-dihydroxy-l l -ketotetr...
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Cytochrome P-450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs). EETs relax vascular smooth muscle by membrane hyperpolarization. 14,15-Epoxyeicosa-5(Z)-enoic acid (14,15-EE5ZE) antagonizes many vascular actions of EETs. EETs are converted to the corresponding dihydroxyeicosatrienoic acids by soluble epoxide hydrolase (sEH). sEH activity in the bovine arterial...
متن کاملSynthesis and Molecular Structures of (E)-non-2-enoic Acid and (E)-dec-2-enoic Acid
The molecular structures of (E)-non-2-enoic acid (C9) and (E)-dec-2-enoic acid (C10) are reported. The title compounds were crystallized by slow evaporation of ethanolic solutions at −30 °C. C9 crystallizes in the monoclinic space group P21/c and C10 in the triclinic space group P-1, each with 4 molecules in the unit cell. The unit cell parameters for C9 are: a = 10.6473(4) Å, b = 5.2855(2) Å, ...
متن کامل(Z)-3-(Benzylcarbamoyl)prop-2-enoic acid
The title compound, C(11)H(11)NO(3), was synthesized by the reaction of maleic andydride and phenyl-methanamine. The mol-ecular conformation is stabilized by by an intra-molecular O-H⋯O hydrogen bond. In the crystal, mol-ecules are linked by inter-molecular N-H⋯O and C-H⋯O hydrogen bonds, forming a chain along the b axis.
متن کاملStudies in valine biosynthesis. III. Biological distribution of a dihydroxy acid dehydrase.
The steps in the pathway of formation of valine are: decarbosylation of pyruvate to an acetaldehyde-thiamine pyrophosphate intermediate which condenses with another molecule of pyruvate to yield ar-acetolactic acid, migration of the a-methyl carbon to form ar-keto-fl-hydroxyisovaleric acid, reduction of this acid to produce (Y ,&dihydroxyisovaleric acid, dehydration to yield ar-ketoisovaleric a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1968
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)93285-0